Study on HMGA1 Gene Polymorphism Site and Its Association with Feed Efficiency Related Traits in Duroc Pigs

The objective of this study was to analyze two SNPs of HMGA1 gene,and investigate its association with feed efficiency related traits in Duroc populations.HMGA1 gene SNPs(g.-543 T > C and g.1356 C > T) in Large White pig and Min pig were detected by re-sequencing technology,SNP genotyping of g.-543 T > C and g.1356 C > T sites in Duroc populations were performed using Sequenom mass spectrometry,and the association of HMGA1 gene SNPs with growth and feed efficiency related traits in Duroc populations were analyzed.The results indicated that the individuals of CT genotype in g.-543 T>C increased 2.15 kg on 90 d body weight (P<0.05),decreased 3.21 d at 30 kg weight age (P<0.05),weaning weight was increased and 100 kg age were decreased,residual feed intake,30 to 100 kg average daily gain (ADG),40 to 90 kg average daily feed intake (ADFI) and 40 to 90 kg ADG were decreased,comparing with CC individuals.Moreover the individuals of CC genotype in g.1356 C>T had significantly increased 90 d body weight (0.37 kg,P<0.05),ADFI (less 0.13 kg,P<0.05),back fat (BF, less 0.43 mm,P<0.05),RFI (less 70.40 g,P<0.05),30 kg age (less 0.56 d,P<0.05) and 40 to 90 kg ADFI (less 0.17 kg,P<0.05) were significantly decreased;Weaning weight and 100 kg age were increased;30 to 100 kg ADG,40 to 90 kg ADG were decreased than TT genotype individuals.And the CT genotype individual in g.1356 C>T had the similar results with CC genotype individuals that compared with TT genotype individuals.All in all,the two SNPs of HMGA1 gene would be helpful in feed efficiency related traits in Duroc population.