Research Progress on Biological Mechanism of Epoxyeicosatrienoic Acids |
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| Authors: | HE Jing Wuyuneerdun Jirimutu Yusiriguleng |
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| Institution: | 1. Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China;2. Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China |
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| Abstract: | Epoxyeicosatrienoic acids (EETs) are synthesized from arachidonic acid by cytochrome P450 epoxygenases.They modulate ion transport and gene expression,producing vasorelaxation as well as antiinflammatory and cell proliferation effects.Many of the functional effects of EETs occur through activation of signal transduction pathways and modulation of gene expression,events probably initiated by binding to a putative cell surface EETs receptor.However,EETs are rapidly taken up by cells and are incorporated into and released from phospholipids,it suggests that some functional effects may occur through a direct interaction between the EETs and an intracellular effector system.EETs synthesis,metabolism,mechanism of action are reviewed in this paper. |
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| Keywords: | epoxyeicosatrienoic acids cell surface receptor ion transport intracellular mechanism |
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