Mechanism of dimerization and activation of CB1 and CB2 receptor |
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Authors: | WU Nan YANG Yang AN Shu GUO Xiao-xi XU Tian-rui LIU Ying |
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Institution: | Cell Signaling Laboratory, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China |
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Abstract: | Cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2) are important members of G protein-coupled receptors (GPCRs). Numerous studies have shown that CB1 receptor can form heterodimers with dopamine receptors (D2), μ-opioid receptor (μOR), orexin-1 receptor, adenosine receptor (A2A) or β2 adrenergic receptors, and then forming an essential functional entity. This review summarizes the research progress on heterodimers of cannabinoid CB1 or CB2, the function of heterodimers as well as the downstream signalings. The different pharmacological properties of the receptor heterodimer lead to bringing a change in receptor pharmacology, which will have a profound impact on drug development. |
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Keywords: | Cannabinoid receptor Dimerization |
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