1株鸡传染性贫血病毒野毒株对不同日龄SPF鸡的致病性

从山东省某商品代肉鸡场表现生长迟缓的20日龄病鸡群分离到1株鸡传染性贫血病毒(CAV)SDLY08株,通过口服和肌肉注射2种途径分别感染1,7,21日龄SPF鸡,12d后检测CAV对SPF鸡体质量、免疫器官和血液指标的影响。结果表明,于3个不同日龄感染后12d,SDLY08株均可导致增重减缓,胸腺显著萎缩,脾脏肿大,同时还可引起白细胞、红细胞数及红细胞压积的显著减少。且1日龄和7日龄鸡易感性大于21日龄鸡,肌肉注射比口服感染组的致病性更强。

Pathogenicity of a chicken infectious anemia virus field isolate in SPF chickens at different ages

A field strain SDLY08 of chicken infectious anemia virus (CAV) was isolated from a 20-day-old broiler flock with growth runting syndromes. SPF chickens at different ages of 1,7,21-day were challenged with the virus by oral administration and intramuscular injection. Ratios of thymuses, spleens and the Bursa to body weight, several blood parameters were examined and compared to controls at 12 d after infectons with CAV. Results indicated that challenges of CAV strain SDLY08 at all 3 ages could cause growth retardation,severe atrophy of thymus and spleen megaly, significant decrease of red blood cells,white blood cells and the haematocrit. It was also demonstrated that 1-day-old and 7-day-old SPF chickens were more sentitive to SDLY08 than 21-day-old chickens,chickens were more sensitive to challenges by intramuscular injection than oral administration.