Polymorphism of the PE domain of PE/PE_PGRS sequences in clinical isolates of Mycobacterium bovis in Mexico |
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| Authors: | Santillan-Flores Marco Antonio Flores Javier Arriaga-Diaz Camila Romero-Torres Cecilia Suárez-Güemes Francisco Espitia Clara |
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| Affiliation: | Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, CENID-Microbiología, Mexico City, Mexico. |
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| Abstract: | Polymorphism of the PE domain of PE/PE_PGRS sequences was studied in Mycobacterium bovis isolates from different Mexican states. Samples were analyzed by spolygotyping and RFLP using IS6110 and a 235-bp fragment of the PE domain of PE/PE_PGRS as probes. With the PE probe, three different genotypes were observed, one being predominant in all states. These results confirm the high conservation of the PE domain and suggests a potential role for PE sequence as a stable genetic marker for bovine tuberculosis. |
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