两种钙拮抗剂对肉鸡PHS的影响

探讨了两种钙拮抗剂(Calcium Antagonists,CA)对肉鸡肺动脉高(Pulmonary Hypertension Syndrome,PHS)的影响,从而较深层地揭示了肉鸡肺动脉高压的形成机理,为预防和治疗肉鸡腹水综合征(Ascites Syndrome.AS)提供理论依据.结果表明:在28和36日龄,硝苯地平与低温组比降低平均肺动脉压(mean Pulmonary Artery Pressure,mPAP),在0.05水平有差异;在44日龄,低温组为3.7kPa±0.7 kPa,硝苯地平组为2.4kPa±0.2 kPa,硝苯地平组mPAP低于低温组,在0.01水平有差异;硝苯地平降低AS的发生率,在0.05水平上有差异.在28和36日龄低温组mPAP为3.4 kP±0.7 kPa和3.4 kPa±1.3 kPa.维拉帕米组mPAP为1.8 kPa±0.8 kPa和1.3 kP±0.3kPa,与低温组比维拉帕米降低mPAP,在0.05水平有差异;44日龄维拉帕米组mPAP低于低温组,在0.01水平有差异.维拉帕米明显降低AS的发生率(P＜0.05).试验结果显示,维拉帕米和硝苯地平降低了低温诱发肺动脉高压和AS的发生率.初步证实钙信号参与了肺动脉高压的形成,对研究AS的发生发展具有重要意义.

Effect of Two Calcium Antagonists on PHS in Broiler

Effect of two calcium antagonists(CA) on pulmonary hypertension syndrome(PHS) was studied and the mechanism of PHS in broilers was discussed,which provided theory basis for the prevention and cure of ascites syndrome(AS).Result showed that the mean pulmonary artery pressure(mPAP) of Nif group decreased compared with low temperature group(LT) in 28 and 36-day-old broilers(P>0.05).The mPAP of Nif group in 44-day-old broilers(2.4±0.2 kPa)was significantly lower than that of LT(3.7±0.7kPa)(P<0.01).And Nif could reduce the incidence of AS(P>0.05).The mPAP of Ver group in 28 and 36-day-old broilers(1.8±0.8 kP and 1.3±0.3 kPa) was lower than that of LT(3.4±0.7 kPa and 3.4±1.3 kPa)(P<0.05).The mPAP of Ver group was significantly lower than that of LT at 44 d(P<0.01).Ver could reduce the incidence of AS(P<0.05).Therefore,Ver and Nif decreased mPAP and the incidence of AS.It was concluded that calcium signal played a certain role in the development of PHS and had important function in the occurrence and development of AS.