复方伊维菌素乳液在山羊体内的药代动力学研究

为了探讨复方伊维菌素乳液在动物体内的药物代谢，为兽医临床提供用药参考。试验选取7只山羊，每只山羊按0.1 mL/kg (伊维菌素0.2 mg/kg, 阿苯达唑10 mg/kg)剂量口服，给药后0.5、1、2、3、4、6、8、12、16、24、36、48、60 h颈静脉采血5 mL，分离血清，-20 ℃保存，用高效液相色谱仪检测样品血药浓度。试验结果表明，①伊维菌素在山羊体内的代谢情况为：0.5 h，0.112151 μg/mL； 第1次达峰时间为4 h, 0.302702 μg/mL；第2次达峰时间为16 h，0.258284 μg/mL；60 h，0.011118 μg/mL。②阿苯达唑在山羊体内的代谢情况为：0.5 h, 0.049285 μg/mL；第1次达峰时间为8 h，4.95283 μg/mL ；第2次达峰时间为16 h，5.694551 μg/mL；60 h，0.06434 μg/mL。复方伊维菌素中的伊维菌素和阿苯达唑在山羊体内代谢时间短，第60小时已达到很低的血药浓度。

Study on Pharmacokinetics of Ivermectin Emulsion Compound in Goats

To investigate the pharmacokinetics of Ivermectin emulsion compound in vivo, and to provide the medical information for the veterinary clinical diagnosis, 7 goats as experimental models were selected, and each goat was given orally Ivermectin emulsion compound by dose of 0.1 mL/kg (Ivermectin 0.2 mg/kg, Albendazole 10 mg/kg). Blood samples were respectively taken 5 mL from Jugular vein at 0.5, 1, 2, 3, 4, 6, 8, 12, 16, 24, 36, 48 and 60 h after administration, then the serum were separated and stored at -20 ℃. High performance liquid chromatography (HPLC) method was used to detect serum drug level. The results showed that: ①The metabolism of Ivermectin in goat: the drug concentration was 0.112151 μg/mL after 0.5 h; the first peak time was 0.302702 μg/mL after 4 h, and the second peak time was both 0.258284 μg/mL after 16 h and 0.011118 μg/mL after 60 h. ②Albendazole metabolism in goats:the drug concentration was 0.049285 μg/mL after 0.5 h; the first peak time was 4.95283 μg/mL after 8 h, and the second peak time were both of 5.694551 μg/mL after 16 h and 0.06434 μg/mL after 60 h.The metabolized time of Ivermectin and Albendazole of Ivermectin emulsion compound in goat was very short, and the drug concentration in serum was not too low until 60 h.