| 细菌生物膜与细菌耐药性研究进展 |
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| 引用本文： | 黄伟,李旭廷,刘兴福.细菌生物膜与细菌耐药性研究进展[J].内蒙古畜牧科学,2012(8):81-83. |
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| 作者姓名： | 黄伟 李旭廷 刘兴福 |
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| 作者单位： | [1]四川鼎尖动物药业有限责任公司,四川成都610100 [2]四川省畜牧科学研究院,四川成都610066 [3]辽宁省喀左县畜产品安全监察所,辽宁喀左122300 |
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| 基金项目： | 四川省畜牧科学研究院基本科研业务费项目（SASA2009A01） |
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| 摘 要： | 细菌生物膜是一种包裹于细胞外多聚物基质中的黏附于非生物或生物表面的微生物菌落。作为一种生存策略,绝大多数细菌在合适的条件下都会产生生物膜,生物膜状态下的细菌相对其游离状态有着更强的耐药性,是导致临床上出现难治性感染的重要原因之一。主要综述了生物膜的形成、耐药机制及抗生物膜的策略,以便寻找有效控制生物膜相关感染的手段,指导临床合理用药和新药开发。
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| 关 键 词： | 细菌生物膜 耐药性 研究进展 细菌 |
The Research Progress of Bacterial Biofilm and Drug Resistance |
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| HUANG Wei,LI Xu-tingz,LIU Xing-fu.The Research Progress of Bacterial Biofilm and Drug Resistance[J].Inner Mongolian Journal of Animal Sciences and Production,2012(8):81-83. |
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| Authors: | HUANG Wei LI Xu-tingz LIU Xing-fu |
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| Institution: | 1.Sichuan Pharmaceutical Industry Animal Limited Liability Company, Chengdu 610100,China;2.Sichuan Animal Husbandry Scientific Research Institute, Chengdu 610066,China;3.Animal Products Safety Supervision Institute of Kazuo County, Kazuo 122300, China) |
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| Abstract: | Bacterial biofilm is a biopolymer matrix-enclosed bacterial population adherent to biotic or abiotic surfaces. This adaptation has been implicated as a survival strategy. Most of bacteria can form biofilm under proper conditions. Antibiotics are generally not very effective against organisms embedded in biofilms （sessile bacteria） in comparison with free-floating organisms （planktonic bacteria）. This was one of the important reasons why infections were difficult to treat nowadays. How to form the biofilm, drug resistance mechanism and diseases caused by bacterial biofilm were conclude in this paper. The effective control methods were discussed. The information was useful to direct using antibiotics reasonable and developing new drugs. |
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| Keywords: | bacterial biofilm drug resistance research progress bacteria |
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