Arterial blood gas tensions during recovery in horses anesthetized with apneustic anesthesia ventilation compared with conventional mechanical ventilation |
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| Institution: | 1. Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA;2. Innovative Veterinary Medicine, Ponte Vedra, FL, USA;3. Department of Statistics, College of Arts and Science, University of Missouri, Columbia, MO, USA;4. Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA;1. Clinical Unit of Anaesthesiology and Perioperative Intensive Care, University of Veterinary Medicine Vienna, Vienna, Austria;2. Unit of Ethics and Human-Animal Studies, University of Veterinary Medicine Vienna, Medical University of Vienna, University of Vienna, Vienna, Austria;1. Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA;2. Institute of Bioinformatics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA;3. Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA;4. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA;1. Dick White Referrals, Station Farm, Six Mile Bottom, Cambridgeshire, UK;2. Hospital Veterinari Glòries, Barcelona, Spain;3. Department of Comparative, Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, FL, USA |
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| Abstract: | ObjectiveTo compare PaO2 and PaCO2 in horses recovering from general anesthesia maintained with either apneustic anesthesia ventilation (AAV) or conventional mechanical ventilation (CMV).Study designRandomized, crossover design.AnimalsA total of 10 healthy adult horses from a university-owned herd.MethodsDorsally recumbent horses were anesthetized with isoflurane in oxygen inspired oxygen fraction = 0.3 initially, with subsequent titration to maintain PaO2 ≥ 85 mmHg (11.3 kPa)] and ventilated with AAV or CMV according to predefined criteria 10 mL kg–1 tidal volume, PaCO2 40–45 mmHg (5.3–6.0 kPa) during CMV and < 60 mmHg (8.0 kPa) during AAV]. Horses were weaned from ventilation using a predefined protocol and transferred to a stall for unassisted recovery. Arterial blood samples were collected and analyzed at predefined time points. Tracheal oxygen insufflation at 15 L minute–1 was provided if PaO2 < 60 mmHg (8.0 kPa) on any analysis. Time to oxygen insufflation, first movement, sternal recumbency and standing were recorded. Data were analyzed using repeated measures anova, paired t tests and Fisher’s exact test with significance defined as p < 0.05.ResultsData from 10 horses were analyzed. Between modes, PaO2 was significantly higher immediately after weaning from ventilation and lower at sternal recumbency for AAV than for CMV. No PaCO2 differences were noted between ventilation modes. All horses ventilated with CMV required supplemental oxygen, whereas three horses ventilated with AAV did not. Time to first movement was shorter with AAV. Time to oxygen insufflation was not different between ventilation modes.ConclusionsAlthough horses ventilated with AAV entered the recovery period with higher PaO2, this advantage was not sustained during recovery. Whereas fewer horses required supplemental oxygen after AAV, the use of AAV does not preclude the need for routine supplemental oxygen administration in horses recovering from general anesthesia. |
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| Keywords: | apneustic anesthesia ventilation conventional mechanical ventilation horse recovery |
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