早期静脉输注高氧液治疗脑弥漫性轴索损伤的临床研究

目的 :探讨早期静脉输注高氧液在脑弥漫性轴索损伤 (DAI)中的治疗作用。方法 :将 10 8例 DAI患者按纳入时间顺序分为早期静脉输注高氧液组 (治疗组 ,n=5 4)和对照组 (n=5 4) ,两组在常规治疗基础上 ,治疗组加予早期静脉输注高氧液。于治疗前后行 GCS评分 ,并评价其临床疗效。结果 :治疗组及对照组 (除治疗后 10 d外 ) GCS评分在治疗后不同时期均明显增加 (P<0 .0 1) ,但以治疗组更为显著 ;治疗组的病死率为 2 2 .2 % ,明显低于对照组的 40 .7% (P<0 .0 1) ,且未发现明显副作用。结论 :早期静脉氧疗可显著改善 DAI患者的意识状态及其神经功能 ,降低病死率 ,有推广应用的价值。

Diffuse axonal injury treated by early intravenous infusion of pleonectic solution

Objective: To study the role of early intravenous infusion of pleonectic solution in diffuse axonal injury (DAI). Methods: According to the admission time, 108 patients with DAI were divided into 2 groups: treatment group received conventional therapy and early intravenous infusion of pleonectic solution, and control group only accepted conventional therapy. Glasgow coma scale (GCS) and therapeutic efficacy were recorded in all cases. Results: Except the postoperative 10th day in control group, GCS was significantly improved in 2 groups (P<0.01), especially in treatment group. The mortality was remarkably lower in treatment group than that in control group (22.2% vs 40.7%,P<0.01). There were no obvious side effects in treatment group. Conclusion: The early use of intravenous oxygen therapy could improve the conscious state and nervous function, and decrease the mortality of DAI patients.