| 甲状腺乳头状癌p53蛋白的表达及临床意义 |
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| 引用本文： | 罗国庆,吴华,吴冬梅.甲状腺乳头状癌p53蛋白的表达及临床意义[J].湛江医学院学报,2001,19(5):335-336. |
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| 作者姓名： | 罗国庆 吴华 吴冬梅 |
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| 作者单位： | [1]广东医学院附属医院耳鼻喉科，广东湛江524001 [2]广东医学院附属医院放疗科，广东湛江524001 [3]广东医学院附属医院病理科，广东湛江524001 |
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| 摘 要： | 目的：观察p53蛋白在甲状腺乳头状癌中的表达及临床意义。方法；采用免疫组化S-P法，对68例甲状腺乳头状癌和10例正常甲状腺组织检测，用有关统计学方法结合临床及随访资料进行分析。结果：68例甲状腺乳头状癌中．p53蛋白阳性率为27．9％。正常甲状腺组织阴性。甲状腺乳头状癌病理分级、有无淋巴结转移与p53蛋白阳性表达率有关。结论：甲状腺乳头状癌预后可能与p53蛋白过度表达有关。
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| 关 键 词： | 甲状腺肿瘤 免疫组化 p53蛋白 预后 |
| 文章编号： | 1005-4057(2001)-05-0335-02 |
| 修稿时间： | 2000年12月10 |
Expression of p53 protein in papillary adenocarcinoma of thyroid gland and its clinical significane |
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| LUO Guo qing,WU Hua,WU Dong mei.Expression of p53 protein in papillary adenocarcinoma of thyroid gland and its clinical significane[J].Journal of Guangdong Medical College,2001,19(5):335-336. |
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| Authors: | LUO Guo qing WU Hua WU Dong mei |
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| Abstract: | Objective:To observe the expression of p 53 protein in papillary adenocarcinoma of thyroid gland and its clinical significance.Methods:Sixty eight samples of with papillary adenocarcinoma of thyroid gland and 10 samples of normal thyroid were examined with S P method.Their clinical and follow up data were also analysed.Results:The positive expression rate of p53 protein was 27.9% in patients with papillary adenocarcinoma of thyroid gland,while the normal thyroid showed negative expression.The pathological grading and presence or absence of lymphatic metastasis of thyroid papillary adenocarcinoma were related to the positive expression of p53 protein.Conclusion:The expression of p53 protein may relate the prognosis of thyroid papillary adenocarcinoma. |
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| Keywords: | thyroid neoplasm immunohistochemistry p53 protein prognosis |
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