Antinociceptive activity of the pyranocoumarin seselin in mice |
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| Authors: | Lima Vilma Silva Caio B Mafezoli Jair Bezerra Mirna M Moraes M Odorico Mourão Guilherme S M M Silva J Nunes Oliveira M Conceição F |
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| Affiliation: | aHealth Sciences Center, Course of Pharmaceutical Sciences, University of Fortaleza (UNIFOR), Fortaleza, Brazil;bDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará (UFC), Fortaleza, Brazil;cFaculty of Medicine, Federal University of Ceará (UFC), Sobral, Brazil;dDepartment of Organic and Inorganic Chemistry, Federal University of Ceará (UFC), Fortaleza, Brazil |
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| Abstract: | Seselin an angular pyranocoumarin at dose of 0.5, 4.5 or 40.5 mg/kg inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4%, respectively. Using the same doses, seselin elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively. Besides, a significant reduction of licking time was observed during the first phase (neurogenic) at the highest doses of seselin, by 34.4% and 66.9%, respectively. On the contrary, in the hot plate test no effect was observed after seselin treatment. In conclusion, seselin was able to inhibit inflammatory hyperalgesia, suggesting that this natural product possesses both important peripheral anti-inflammatory and antinociceptive properties. |
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| Keywords: | Antinociceptive Seselin Pyranocoumarin |
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