油酸诱导大鼠肺水肿动物模型的建立 |
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引用本文: | 张青峰,王燕,姬可平,唐历波. 油酸诱导大鼠肺水肿动物模型的建立[J]. 安徽农业科学, 2010, 38(30): 16962-16963,16975 |
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作者姓名: | 张青峰 王燕 姬可平 唐历波 |
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作者单位: | 遵义医学院珠海校区,广东珠海519041 |
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基金项目: | 遵义医学院教改课题资助 |
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摘 要: | [目的]制备油酸诱导大鼠肺水肿的动物模型,便于进行肺水肿的发病机制和相关治疗的研究。[方法]将试验大鼠随机分为对照纽和油酸组,尾静脉注射油酸0.2ml/kg,观察动物的体征变化及病理切片,确定大鼠肺水肿动物模型。[结果]油酸能引起大鼠肺水肿,其临床症状和病理变化明显。[结论]油酸诱发的肺水肿模型临床症状典型、方法简单、成本低、便于操作且重复性好,能为教学、临床、科研提供较为理想的动物模型。
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关 键 词: | 肺水肿 大鼠 动物模型 油酸 |
Establishment of Oleic Acid-Induced Animal Model of Pulmonary Edema in Rats |
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Affiliation: | ZHANG Qing-feng et al (Zhuhai Campus, College of Zunyi Medicine, Zhuhai, Guangdong 519041 ) |
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Abstract: | [Objective]To establish an animal model of pulmonary edema in rats in order to serve the study on mechanisms and treatment of pulmonary edema.[Methods]The white rats were randomly divided into control and ammonium chloride groups.The pulmonary edema was established by injecting oleic acid 0.2 ml/kg into the tail vein.The rats condition,pulmonary ratio and pathologic section were observed to identify the pulmonary edema model.[Result]The ammonium chloride could induce acute pulmonary edema and had its own character.[Conclusion]The model of the pulmonary edema induced by ammonium chloride is ideal.The symptom is obvious,and the animal model is feasible and economic. |
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Keywords: | Pulmonary edema Rats Animal model Oleic acid |
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