油酸诱导大鼠肺水肿动物模型的建立

目的]制备油酸诱导大鼠肺水肿的动物模型，便于进行肺水肿的发病机制和相关治疗的研究。方法]将试验大鼠随机分为对照纽和油酸组，尾静脉注射油酸0．2ml／kg，观察动物的体征变化及病理切片，确定大鼠肺水肿动物模型。结果]油酸能引起大鼠肺水肿，其临床症状和病理变化明显。结论]油酸诱发的肺水肿模型临床症状典型、方法简单、成本低、便于操作且重复性好，能为教学、临床、科研提供较为理想的动物模型。

Establishment of Oleic Acid-Induced Animal Model of Pulmonary Edema in Rats

Objective]To establish an animal model of pulmonary edema in rats in order to serve the study on mechanisms and treatment of pulmonary edema.Methods]The white rats were randomly divided into control and ammonium chloride groups.The pulmonary edema was established by injecting oleic acid 0.2 ml/kg into the tail vein.The rats condition,pulmonary ratio and pathologic section were observed to identify the pulmonary edema model.Result]The ammonium chloride could induce acute pulmonary edema and had its own character.Conclusion]The model of the pulmonary edema induced by ammonium chloride is ideal.The symptom is obvious,and the animal model is feasible and economic.