Potentiation of thein vitro activity of some antimicrobial agents against selected Gram-negative bacteria by EDTA-tromethamine |
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| Authors: | A. M. Farca P. Nebbia G. Re |
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| Affiliation: | (1) Department of Animal Pathology, Division of Pharmacology and Toxicology, University of Turin, Turin, Italy;(2) Department of Epidemiology, Animal Productions and Ecology, Division of Infectious Diseases, University of Turin, Turin, Italy |
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| Abstract: | Thein vitro synergistic effects of combinations of EDTA-tromethamine and six antimicrobial agents (ampicillin, chloramphenicol, oxytetracycline, streptomycin, nalidixic acid and sulphadimethoxine) on clinically isolated strains ofPseudomonas aeruginosa, Proteus mirabilis andEscherichia coli were investigated. The antibacterial activity was assessed from the minimal inhibitory concentration for the antibiotics alone or in combination with EDTA-tromethamine. EDTA-tromethamine potentiated the antibacterial activity of ampicillin, chloramphenicol, oxytetracycline and streptomycin up to four-fold. There were no significant or consistent synergistic effects with nalidixic acid or sulphadimethoxine.Abbreviations cfu colony-forming units - EDTA ethylenediaminetetraacetic acid - MIC minimal inhibitory concentration - tromethamine tris(hydroxymethyl)aminomethanePart of this paper was communicated at the XLV Congress of the Italian Society of Veterinary Sciences, Palermo, 25–28 September 1991 |
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| Keywords: | antibiotics bacteria Gram-negative EDTA ethylenediaminetetraacetic acid minimal inhibitory concentration potentiation tromethamine |
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