无尾鸡骨骼发育关键信号通路研究进展

骨骼系统对机体的生命活动至关重要,它为生物体提供了造血微环境、机械支撑、保护脏器等功能,同时也是钙和其他矿物质等的储存库。家鸡尾骨的表型多样性是研究骨骼系统发育及形成机制的良好资源。Notch、Wnt信号通路的靶基因及其相互作用可以形成周期性表达的特点,是调节体节形成及尾部骨骼终止延伸的分子通路。为了解无尾鸡骨骼发育终止的分子机制,作者分别总结了骨骼发育、无尾鸡骨骼研究进展,并重点讨论影响无尾性状的关键信号通路Notch、Wnt及其在无尾鸡研究中的进展。但是,受体和配体之间相互作用的精确调节以及信号通路中的核心元素仍不清楚,需要通过更多的功能基因组和蛋白质组等方法进行深入研究。

Research Progress on Key Signaling Pathways in Bone Development of Rumpless Chicken

The skeletal system is crucial to the life activities of the organism,it provides the hematopoietic micro-environment,mechanical support,organ protection and other functions,as well as a reservoir of calcium and other minerals.The phenotypic diversity of chicken tailbone is a good resource for study of skeletal phylogeny and mechanism.To understand the molecular mechanism of skeletal developmental termination in the Rumpless chicken,this paper summarized the development of skeletal,the skeletal research in Rumpless chicken,and focus on the key signaling pathways of Notch and Wnt that influence the characteristics of rumpless and research progress of the Rumpless chicken.Target genes of Notch and Wnt signaling pathways and their interactions can form the characteristic of periodic expression,which is a molecular pathway regulating body segment formation and tailbone extension.However,the precise regulation of the interaction between the receptor and ligand and the core elements in the signaling pathway are still unclear,and more functional genomic and proteomic technology are needed for further study.