Amphotericin B methyl ester hydrochloride and amphotericin B: comparative acute toxicity |
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Authors: | G R Keim J W Poutsiaka J Kirpan C H Keysser |
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Abstract: | In single-dose parenteral studies with mice and dogs, the methyl ester hydrochloride of amphotericin B proved to be significantly less toxic than the parent compound, especially to the kidney. |
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