| 葡萄糖基聚合物的酶催化合成及其在制备缓释微球中的应用 |
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| 引用本文： | 王银珍,姚评佳,魏远安.葡萄糖基聚合物的酶催化合成及其在制备缓释微球中的应用[J].广西农业生物科学,2009(2):321-325. |
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| 作者姓名： | 王银珍 姚评佳 魏远安 |
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| 作者单位： | 广西大学化学化工学院;广西大学生命科学与技术学院;广西亚热带生物资源保护利用重点实验室; |
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| 基金项目： | 国家自然科学基金(20366002-2);;广西科技创新能力与条件建设项目(桂能科0630006-5B)资助 |
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| 摘 要： | 以脂肪酶Novozym-435催化葡萄糖和10- 十一碳烯酸合成了6-O-（10- 十一碳烯酸）-葡萄糖酯，在K2S2O8引发下合成了葡萄糖基聚合物。采用复凝聚法以葡萄糖基聚合物和海藻酸钠为基质材料，将非诺洛芬钙包裹制成缓释微球。通过L9（3^4）正交实验得出微球的最佳制备工艺条件，结果是葡萄糖基聚合物：海藻酸钠质量比=1：2，pH3.0，搅拌速度400r／min，反应成球温度45℃。在最佳工艺条件下制备的非诺洛芬钙缓释微球，粒径范围是10-20μm，平均药物包封率（73.74±3.12）％。同时，体外溶出试验表明，该微球具有较好的缓释作用。
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| 关 键 词： | 葡萄糖基聚合物 酶催化合成 微球 缓释制剂 |
Enzyme-catalyzed Synthesis of Glucose-based Polymers and its Application on Preparation of Sustained-release Microspheres |
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| Wang Yinzhen Yao Pingjia , Wei Yuanan College of Chemistry & Chemical Engineering,Guangxi University,Nanning , College of Life Science & Technology,Guangxi University Nanning, Guangxi Key Laboratory of Subtropical Bio-resource Conservation , Utilization,Nanning.Enzyme-catalyzed Synthesis of Glucose-based Polymers and its Application on Preparation of Sustained-release Microspheres[J].Journal of Guangxi Agricultural and Biological Science,2009(2):321-325. |
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| Authors: | Wang Yinzhen Yao Pingjia Wei Yuanan College of Chemistry & Chemical Engineering Guangxi University Nanning College of Life Science & Technology Guangxi University Nanning Guangxi Key Laboratory of Subtropical Bio-resource Conservation Utilization Nanning |
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| Institution: | Wang Yinzhen 1 Yao Pingjia 2,3 Wei Yuanan 3 1 College of Chemistry & Chemical Engineering,Guangxi University,Nanning 530004,2 College of Life Science & Technology,Guangxi University Nanning,530005,3 Guangxi Key Laboratory of Subtropical Bio-resource Conservation , Utilization,Nanning |
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| Abstract: | After immobilized lipase enzyme Novozym-435 catalyzed glucose and undecylenic to regioselective synthesis 6-O-(10-undecylenoyl) D-glucose,the glucose-based polymer were prepared using K2S2O8 as a chemical initiator. The suitable sustained-release microspheres containing fenoprofen calcium were prepared using glucose-based polymers and sodium alginate as base materia1. The L9(34) orthogonal experimental design to optimize the preparation procedure of the microspheres. The result showed that the mass ratio of... |
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| Keywords: | Glucose-based polymers Enzyme-catalyzed synthesis Microspheres Sustained-release procedures |
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