灭菌散对仔猪腹泻的防治研究

仔猪腹泻是一种主要由大肠杆菌引起的危害严重的疾病,在养猪生产中,特别是采用仔猪早期断奶技术后普遍存在.本试验根据中兽医学的基础理论和仔猪腹泻的临床表现,研制了一种中药制剂-灭菌散.选择以黄连、黄柏、黄芪、甘草、白头翁、干姜和大蒜等20多种中草药为主组成的灭菌散制剂,煎成1g/mL的中药汤剂,以0.2%的比例添加到日粮中.选择(28±1)日龄杜长大断奶仔猪60头,随机分成2组,每组30头.2组均饲喂基础日粮,试验组另添加0.2%的中药汤剂.给药后8 d,每组选择5头,前腔静脉采血做血液学和免疫学指标检测.试验结果表明,0.2%中药汤剂能有效预防仔猪腹泻,并能提高RBC、TP、IgG的数量和水平,腹泻率较对照组下降33.7%(P＜0.01).灭菌散是一种能有效防治仔猪腹泻的候选制剂.

The effects of MIEJUNSAN on controlling piglet diarrhea

Piglet diarrhea is a severe disease caused by Escherichia coli (E. coli) in pig farms, especially after piglet early weaning technique has been applied. According to the symptoms of piglet diarrhea and traditional Chinese veterinary theory, MIEJUNSAN, a Chinese medicine herb preparation was studied. There are 20 kinds of Chinese medical herbs in the basic recipe such as Huanglian (Coptis chinensis Franch), Huangbai (Phellodendron amurense Rupr. ), Huangqi (Scutellaria baicalensis Georgi ), Gancao (Glycyrrhiza uralensis Fisch), Baitouweng( Radix Pulsatilla), dry zingiber and garlic. 60 piglets ( Duroc × Landrace × Large white), weaned on (28 ± 1 )days, were chosen and divided randomly into two groups, 30 piglets each group. They were raised with basic dietary but added 0. 2% decoction ( 1: 500 in drink water) in the experimental group. Blood samples were taken from cranial vena cava of 5 piglets in each group on the eighth day after treatment to assay the hematological and immunological indices. The results showed that, compared with control, the 0.2% decoction could control piglet diarrhea and rise the RBC, TP, IgG level and reduce significantly the diarrhea rate by 33.7% ( P ＜ 0. 01 ).MIEJUNSAN may be a candidate preparation to control piglet diarrhea.