The cytokines of bovine mammary gland: prospects for diagnosis and therapy |
| |
Authors: | Alluwaimi Ahmed M |
| |
Affiliation: | Department of Microbiology and Parasitology, College of Veterinary Medicine and Animal Resources, King Faisal University, PO Box 35252, Al-Alhsaa 31982, Saudi Arabia. alluwaimi@kfu.edu.sa |
| |
Abstract: | The lack of efficacy of conventional strategies for the maintenance of healthy udders in domestic cattle has prompted studies on the use of cytokines for this purpose. The adjuvant use of recombinant bovine cytokines, such as IL-2, IFN-gamma and TNF-alpha, in normal mammary gland, mobilizes innate and acquired immunity. However, stimulated immunity does not prevent or eradicate infection, particularly in the case of Staphylococcus aureus mastitis. Cytokines do, however, improve the bactericidal efficiency of certain antibiotics. The subtle and sensitive changes in the cytokine network of normal and mastitic bovine mammary gland may encourage the use of cytokines in the diagnosis and prognosis of udder health. Numerous studies support this hypothesis, and detection and monitoring of cytokines could become an important alternative management for udder health. The use of cytokines in the immunotherapy, diagnosis and prognosis of mastitis will grow with knowledge of the cytokine network in bovine mammary glands and the development of efficient cytokine diagnostic techniques. |
| |
Keywords: | Cytokines Mastitis Interleukins Bovine Diagnosis Therapy IL-8 |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|