| 7 羟基 4 甲基香豆素钠盐的合成及结构表征 |
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| 引用本文： | 李 振,周 乐,宋晓平.7 羟基 4 甲基香豆素钠盐的合成及结构表征[J].西北农业学报,2011,20(10):173-175. |
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| 作者姓名： | 李 振 周 乐 宋晓平 |
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| 作者单位： | 西北农林科技大学动物医学院中兽医药研究所;西北农林科技大学理学院; |
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| 基金项目： | “十一五”国家科技支撑计划(2008BADB4B05) |
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| 摘 要： | 以7-羟基-4-甲基香豆素与氢氧化钠为原料合成标题化合物,并进行重结晶溶剂筛选及纯化精制,采用TLC、UV、IR、1H NMR、13C NMR和MS进行结构表征。结果表明,7-羟基-4-甲基香豆素与氢氧化钠较易形成钠盐,在水-丙酮中易形成结晶,用体积分数为92%丙酮溶液重结晶可得到淡黄色针状晶体,产率75%。该方法操作简单,成本低廉,对规模化生产具有重要指导意义。
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| 关 键 词： | 7-羟基-4-甲基香豆素钠盐 合成 重结晶 结构表征 |
Synthesis and Structural Characterization of 7 hydroxy 4 methylcoumarin Sodium Salt |
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| LI Zhen,ZHOU Le and SONG Xiaoping.Synthesis and Structural Characterization of 7 hydroxy 4 methylcoumarin Sodium Salt[J].Acta Agriculturae Boreali-occidentalis Sinica,2011,20(10):173-175. |
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| Authors: | LI Zhen ZHOU Le and SONG Xiaoping |
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| Institution: | LI Zhen1,ZHOU Le2 and SONG Xiaoping1(1.Institute of Traditional Chinese Veterinary Medicine,College of Veterinary Medicine,Northwest A&F University,Yangling Shaanxi 712100,China,2.College of Science,China) |
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| Abstract: | 7-hydroxy-4-methylcoumarin sodium salt was prepared by reaction of 7-hydroxy-4-methylcoumarin with sodium hydroxide,and a solvent for its recrystallization was screened to purify the product.The structure of the title compound was characterized by TLC,UV,IR,1H NMR,13C NMR and MS analysis.The results showed that the product was obtained easily and recrystallization in the solution of 92% acetone in water provided pale yellow needle crystal with yield of 75%.The present method was simple and low cost,and had ... |
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| Keywords: | 7-hydroxy-4-methylcoumarin sodium salt Synthesis Recrystallization Structural characterization |
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