Toll-like receptor-mediated anti-inflammatory action of glaucine and oxoglaucine |
| |
| Authors: | Mimi Remichkova Petya Dimitrova Stefan Philipov Nina Ivanovska |
| |
| Institution: | aDepartment of Immunology, The Stephan Angeloff Institute of Microbiology, 1113 Sofia, Bulgaria;bDepartment of Chemistry of Natural Products, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria |
| |
| Abstract: | Two isochinoline alkaloids, glaucine and oxoglaucine were investigated for their suggested anti-inflammatory influence concerning nitric oxide and cytokine production. Mouse peritoneal macrophages were stimulated with different Toll-like receptor (TLR) ligands such as LPS for TLR4, zymosan for TLR2 and CpG for TLR9. The alkaloids inhibited TNF-α and IL-6 production induced by these ligands. In regard to IL-12 suppressive effect was registered in the case of CpG stimulation. Glaucine succeeded to enhance LPS and zymosan-induced IL-10 production. The reduction of pro-inflammatory cytokines and increase of anti-inflammatory IL-10 are indicative for their use in different acute and chronic inflammatory diseases. |
| |
| Keywords: | Glaucine Oxoglaucine Toll-like receptors Macrophages Cytokines Nitric oxide |
| 本文献已被 ScienceDirect 等数据库收录！ |
