恩诺沙星注射液在猪体内的残留消除研究

为研究恩诺沙星在猪体内的残留消除规律,验证休药期,以2.5 mg/kg体重肌内注射10%恩诺沙星注射液,每日2次,连续3 d。在最后一次给药后0、3、5、7、10 d时间点,采集肌肉、肝脏、肾脏、脂肪和注射部位肌肉,HPLC法测定组织中的恩诺沙星及其代谢物环丙沙星的残留量,并用WT1.4软件计算休药期。结果显示,恩诺沙星在猪肌肉、肝脏、肾脏、脂肪和注射部位肌肉的休药期分别是5.6、13.4、8.2、3.0、5.5 d。为保证兽药使用安全、消费者健康和食品安全,推荐恩诺沙星注射液在猪的休药期为14 d。

Residue Depletion Study of Enrofloxacin Injection in Swine

The residue depletion of enrofloxacin injection in the swine was studied. The preparation of 10% concentration was administrated intramuscularly at a dose of 2.5 mg/kg twice daily for 3 days. Tissue samples were collected at 0, 3, 5, 7 and 10 day after the last administration. The concentration of residues including enrofloxacin and ciprofloxacin in tissues were analyzed and the withdrawal time was calculated by WT1.4 software. The result recommended that the withdrawal time of the 10% enrofloxacin injection in swine would be 14 days.