Use of a modified-live vaccine to prevent persistent testicular infection with bovine viral diarrhea virus |
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Authors: | Givens M Daniel Riddell Kay P Zhang Yijing Galik Patricia K Stringfellow David A Brodersen Bruce W Jackson James A Ellsworth Michael A Ficken Martin D Carson Robert L Wenzel James G W Marley M Shonda |
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Affiliation: | Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA. |
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Abstract: | A commercial vaccine containing modified-live bovine viral diarrhea virus (BVDV; types 1 and 2) was administered to one group of 22 peripubertal bulls 28 days before intranasal inoculation with a type 1 strain of BVDV. A second group of 23 peripubertal bulls did not receive the modified-live BVDV vaccine before intranasal inoculation. Ten of 23 unvaccinated bulls--but none of the vaccinated bulls--developed a persistent testicular infection as determined by immunohistochemistry and polymerase chain reaction. Results of this study indicate that administration of a modified-live vaccine containing BVDV can prevent persistent testicular infection if peripubertal bulls are vaccinated before viral exposure. |
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