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| 苦参碱对低钾致兔左心室流出道细胞电生理异常保护作用及其机制 | |
| 引用本文： | 王雪芳,刘艳明,吕英雷. 苦参碱对低钾致兔左心室流出道细胞电生理异常保护作用及其机制[J]. 河北北方学院学报(自然科学版), 2011, 27(5): 59-61 |
| 作者姓名： | 王雪芳 刘艳明 吕英雷 |
| 作者单位： | 1. 河北北方学院基础医学院生理教研室,河北张家口,075000 2. 中国人民解放军第251医院心内二科,河北张家口,075000 3. 河北北方学院临床医学2010级4班,河北张家口,075000 |
| 基金项目： | 河北省中医药管理局资助项目 |
| 摘 要： | 目的探讨苦参碱对低钾致兔左心室流出道细胞电生理异常保护作用及其机制.方法应用常规玻璃微电极细胞内记录技术,观察正常灌流液、低钾灌流液、低钾＋苦参碱（50μmol/L）灌流液对兔左心室流出道慢反应自律细胞最大舒张电位（MDP）,动作电位0相幅值（APA）,50%复极化时间（APD50）,90%复极化时间（APD90）,4... |
| 关 键 词： | 苦参碱 左心室流出道 低钾血症 电生理 |
Protective Effects of Matrine on Hypokalemia-induced Abnormal Electrophysiology in Rabbits Left Ventricular Outflow Tract Cell and Its Mechanism |
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| WANG Xue-fang,LIU Yan-ming,LV Ying-lei. Protective Effects of Matrine on Hypokalemia-induced Abnormal Electrophysiology in Rabbits Left Ventricular Outflow Tract Cell and Its Mechanism[J]. JournalofHebeiNorthUniversity(NaturalScienceEdition), 2011, 27(5): 59-61 | |
| Authors: | WANG Xue-fang LIU Yan-ming LV Ying-lei |
| Affiliation: | WANG Xue-fang1,LIU Yan-ming2,LV Ying-lei3 (1.Department of physiology,Hebei North University,Zhangjiakou 075000,Hebei,China,2.Department of Cardiology,251st Hospital of PLA,3.Grade 2010,Zhangjiakou,075000,China) |
| Abstract: | Objective To study the electrophysiology effects of Matrine on hypokalemia of guinea pigs left ventricular outflow tract cells.Methods The action potentials were recorded by conventional intracellular microelectrode technique,while the amplitude of action potential（APA）,maximal rate of depolarization（Vmax）,50% and 90% of duration of action potential（APD50 and APD90） and the rate of potential frequency（RPF） in guinea pigs left ventricular outflow tract pacemaker cells of normal control group,hypokalemia group and hypokalemia adding Matrine group were observed.Results Compared with the results of normal controls,action potentials of APD50、APD90 of left ventricular outflow tract pacemaker cells in hypokalemia group were decreased（P0.05）,APA、Vmax、and RPF significantly increased（P0.01）,and there existed arrhythmia.The addition of Matrine（50 μmol/L）could significantly prolong APD50、APD90（P0.05）;APA、Vmax、and RPF significantly decreased（P0.01）.Twenty minutes after reperfusion,spontaneous dischange frequency recovered to the normal control rhythm.Conclusion the result indicates that the automaticity of left ventricular outflow tract pacemaker cells can be influenced by hypokalemia and Matrine can counteract abnormal electrophysiology induced by hypokalemia. |
| Keywords: | Matrine left ventricular outflow tract hypokalemia electrophysiology |
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