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Accidental 5-Fluorouracil Exposure in a Dog |
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| Authors: | Jennifer Roberts DVM Lisa L Powell DVM DACVECC |
| Institution: | Department of Small Animal Clinical Sciences, University of Minnesota, College of Veterinary Medicine, Veterinary Teaching Hospital, St. Paul, Minnesota |
| Abstract: | objective: To demonstrate the range of toxicities with 5-Fluorouracil (5-FU). Case Summary: A one-year-old male castrated Labrador Retriever presented to the University of Minnesota Veterinary Teaching Hospital Emergency Service following accidental ingestion of a 5% 5-Fluorouracil (5-FU) topical antineoplastic cream. The animal presented with status epilepticus and later demonstrated additional clinical signs consistent with 5-FU toxicosis including mucositis and diarrhea, profound but transient leukopenia, and thrombocytopenia. New Information Provided: The calculated ingested dosage was 46 mg/kg. The dog responded well to intensive therapy, recovering uneventfully. |
| Keywords: | Status epilepticus thrombocytopenia mucositis chemotherapy toxicity |