Bone Metabolism Markers in Arabian Horses During the First Two Years of Life |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Tokyo Women''s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan;2. Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan;1. Urology Division, Meijo Hospital, 1-3-1, San-nomaru, Naka-ku, Nagoya 460-0001, Japan;2. Department of Urology, Nagoya City Higashi General Hospital, Nagoya, Japan;3. Department of Urology, Nagoya City University Medical School, Nagoya, Japan;4. Department of Urology, Aihoku Hospital, Nagoya, Japan;1. Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;2. Division of Hematology and Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;3. Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA;4. Department of Medicine, University of Louisville, Louisville, KY, USA;5. Special Hematology Laboratory, US Department of Veterans Affairs Medical Center, Louisville, KY, USA;1. Department of Urology, Kurume University School of Medicine, Kurume, Japan;1. Department of Rehabilitation Medicine, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan;2. First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan;1. Department of Surgery, Kuopio University Hospital, FIN-70210 Kuopio, Finland;2. Department of Biochemistry and Biotechnology, University of Kuopio, United Kingdom;3. Department of Orthopaedics, Sapporo Medical School, Hokkaido, Japan;4. Department of Paediatrics, Juntendo University School of Medicine, Tokyo 113, Japan;5. Gene Analysis Division, Mitsubishi Kagaku BCL, Tokyo, Japan;6. Bone and Mineral Research Division, Garvan Institute of Medical Research, St Vincent''s Hospital, Sydney, Australia;7. Division of Clinical Pathophysiology, Department of Medicine, University Hospital of Geneva, 1211 Geneva 14, Switzerland |
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| Abstract: | Serum markers of bone metabolism were analyzed in Arabian horses from birth through 2 yr. The marker of bone formation utilized was osteocalcin (OC), and the marker for degradation was carboxy-terminal pyridinoline cross-linked telopeptide region of type I collagen (ICTP). Blood samples were taken via jugular venipuncture the day of birth, d 15, d 30, d 45, d 60, and every 30 d thereafter through d 720. Serum was obtained and analyzed for OC and ICTP. Osteocalcin concentrations increased immediately after birth, were variable, and returned to baseline by d 300. By d 330, concentrations of OC began to decrease from d 0 and stayed at this lower concentration through d 510. From d 540 through 720, OC concentrations were similar to baseline. A decrease from baseline (d 0) in ICTP concentrations was seen on d 60, and ICTP continued to decline in concentration through d 720. Therefore, concentrations of OC and ICTP decreased over time as previously reported, and this study characterizes those changes on a monthly basis. Variability and general concentrations for OC and ICTP obtained in this study will provide valuable information for future experimental design and use of these markers in young horses and will aid researchers in determining treatment effects without being confounded by changes in concentrations caused by growth. |
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