| 几种氟喹诺酮类药物对嗜水气单胞菌体外药效学研究 |
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| 引用本文： | 杨雨辉,佟恒敏,卢彤岩,赵吉伟,刘红柏,马力. 几种氟喹诺酮类药物对嗜水气单胞菌体外药效学研究[J]. 东北农业大学学报, 2003, 34(4): 431-435 |
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| 作者姓名： | 杨雨辉 佟恒敏 卢彤岩 赵吉伟 刘红柏 马力 |
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| 作者单位： | 1. 中国水产科学研究院黑龙江水产研究所,150076
2. 东北农业大学,黑龙江,哈尔滨,150030 |
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| 摘 要： | 采用试管两部稀释法测定了盐酸环丙沙星、乳酸环丙沙星、恩诺沙星、单诺沙星、二氟沙星对嗜水气单胞菌的最小抑菌浓度 (MIC)和最小杀菌浓度 (MBC) ,MIC分别是 :0 .0 0 6 2 5 ,0 .0 0 6 2 5 ,0 .0 12 5 ,0 .0 5 ,0 .2 0 ︼g.m L- 1 ,MBC分别是 0 .0 2 5 ,0 .0 2 5 ,0 .0 5 ,0 .10 ,0 .80 ︼g.m L- 1。同时研究了不同药物浓度 (2 MIC,5 MIC,8MIC)对嗜水气单胞菌杀菌的经时变化规律。结果表明 ,这几种药物从 2 MIC到 5 MIC浓度在 3h内菌数减少的 1g值之间差异显著 (P <0 .0 5 ) ,从 5 MIC浓度到 8MIC浓度在 3h内菌数减少的 1g值之间差异不显著 (P >0 .0 5 )
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| 关 键 词： | 氟喹诺酮 嗜水气单胞菌 药效学 |
| 文章编号： | 1005-9369(2003)04-0431-05 |
| 修稿时间： | 2002-10-17 |
Pharmacodynamics of several fluoroquinolones against A.hydrophila in vitro |
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| YANG Yu-hui,TONG Heng-min,LU Tong-yan,ZHAO Ji-wei,LIU Hong-bai,MA Li. Pharmacodynamics of several fluoroquinolones against A.hydrophila in vitro[J]. Journal of Northeast Agricultural University, 2003, 34(4): 431-435 |
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| Authors: | YANG Yu-hui TONG Heng-min LU Tong-yan ZHAO Ji-wei LIU Hong-bai MA Li |
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| Abstract: | The MIC and MBC of Ciprofloxacin hydrochloride,ciprofioxacin lactate,Enrofloxacin,Danofloxacin and Difloxacin were estimated in the paper.Their MIC is 0.00626, 0.00625, 0.0125, 0.05, 0.2 μg·mL -1 ,respectively.Their MBC is 0.025, 0.025, 0.05, 0.1, 0.8 μg·mL -1 ,respectively.The law of the Fluoroquinolones against A.hydrophila in vitro shows that the difference is significant between 2 MIC and 5 MIC,isn't significant between 5 MIC and 8 MIC.There are different character of killing A.hydrophila in the different Fluoroquinolones. |
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| Keywords: | fluoroquinolones A.hydrophila pharmacodynamics |
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