丹参对慢性肺源性心脏病患者血浆神经降压素及神经肽Y含量的影响

目的:观察丹参对慢性肺源性心脏病(CCP)患者血浆神经降压素(NT)及神经肽Y(NPY)含量的影响。方法:用放射免疫分析法测定40例慢性肺源性心脏病患者血浆NT、NPY的水平,并以30例健康者作对照,观察CCP患者常规治疗及在其基础上加用丹参静脉滴注后NT和NPY的水平变化。结果:CCP患者血浆NT和NPY水平均明显高于对照组(P<0.05)。常规治疗及加用丹参治疗后NT、NPY水平均有明显下降,且丹参治疗组较常规治疗组下降更加显著(P<0.05)。结论:丹参可明显降低CCP患者血浆NT、NPY水平,对改善患者缺氧及心功能有重要作用。

Effect of Salviae miltiorrhizae on the plasma level of Neurotensin and Neuropeptide Y in patients with chronic cor pulmonale

Objective: To observe the effect of Salviae miltiorrhizae (SM) on the plasma level of Neurotensin(NT) and Neuropeptide Y(NPY) in patients with chronic cor pulmonale(CCP).Methods:Plasma Levels of NT and NPY were measured by radioimmunoassay(RIA) in 40 CCP patients with the routine treatment only or the routine treatment plus SM administered intravenously,and 30 normal subjects.Results: Plasma levels of NT and NPY in CCP patients were significantly higher than those in normal subjects(P<0.01);Both NT and NPY levels from CCP patients were decreased by the routine treatment or the routine treatment plus SM,but decreased significantly more by the later(P<0.05).Conclusion: SM can clearly lower down the levels of NT and NPY from CCP patients,which suggests that SM might reduce the anoxia to improve the cardiact function of the CCP patients.