新型砜类化合物对辣椒枯萎病菌的抑菌作用初探

离体条件下采用生长速率法测得2-(苄基砜)-5-(2,4-二氯)苯基-1,3,4- NFDA1 二唑( 2008334 )对辣椒枯萎病菌Fusarium oxysporum菌丝生长具有较强的抑制作用,其EC50值为27.54 μ g/mL,与对照药剂 NFDA1 霉灵(EC50值为29.13 μ g/mL)相当;同时该化合物对辣椒枯萎病菌孢子萌发亦有一定的抑制作用,EC50值为41.37 μ g/mL。以质量浓度为100 μ g/mL的 2008334 处理辣椒枯萎病菌菌丝,在短时间内菌丝细胞膜通透性显著增强,菌体内还原糖及可溶性蛋白含量均出现先升高后下降的趋势。

Preliminary study on antifungal activity of new derivative ofsulfone against Fusarium oxysporum

The antifungal activity of 2-(benzylsulfonyl)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole ( 2008334 ) against Fusarium oxysporum was preliminary evaluated with the method of mycelial growth rate in vitro.The results showed that the EC50 value of compound- 2008334 was 27.54 μ g/mL,which was similar with that of hymexazol (29. 13 μ g/mL).The spore germination of F.oxysporum can be inhibited by compound- 2008334 with EC50 value as 41.37 μ g/mL.After treated by 2008334 at 100 μ g/mL,the permeability of the cell membrane increased significantly,and the contents of reducing sugar and soluble protein in mycelia increased for a short time,and decreased subsequently.