Cardiovascular effects of Hyptis fruticosa essential oil in rats |
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| Authors: | Santos M R V Carvalho A A Medeiros I A Alves P B Marchioro M Antoniolli A R |
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| Affiliation: | 1. Laboratório de Farmacologia Cardiovascular, Universidade Federal de Sergipe, Av. Marechal Rondon, S/N, Rosa Elze, CEP: 49100-000, São Cristóvão, SE, Brazil;2. Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, PB, Brazil;3. Departamento de Química, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil |
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| Abstract: | In non-anesthetized normotensive rats, Hyptis fruticosa essential oil (HFEO, 5, 10, 20 and 40 mg/kg; i.v.) induced hypotension associated with tachycardia. In intact and isolated rings of rat superior mesenteric artery (control), HFEO (1-1000 microg/ml, n=6, cumulatively) induced concentration-dependent relaxations of tonus induced by 10 microM phenylephrine (Phe) (pD(2)=2.6+/-0.27; E(max)=64+/-8.3%). In denuded endothelium pre-contracted rings with Phe or K(+)-depolarizing solution (80 mM), the concentration-response curves to HFEO were not shifted (pD(2)=2.3+/-0.25 and 2.3+/-0.28, respectively), but their maximal responses were significantly (P<0.05 vs control) increased (E(max)=122.3+/-18.2% and 92+/-3.6%, respectively). HFEO was also capable of antagonizing the concentration-response curves to CaCl(2) (3 microM-30 mM) in a dose-dependent manner. |
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| Keywords: | Hyptis fruticosa Essential oil Cardiovascular effects |
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