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| 司帕沙星在雏鸡体内药代动力学及残留的研究 | |
| 引用本文： | 刘明春,佟恒敏,朱文波,孙相志,何剑斌,赵玉军.司帕沙星在雏鸡体内药代动力学及残留的研究[J].现代畜牧兽医,2004(11):37-39. |
| 作者姓名： | 刘明春 佟恒敏 朱文波 孙相志 何剑斌 赵玉军 |
| 作者单位： | 1. 沈阳农业大学畜牧兽医学院,辽宁,沈阳,110161 2. 东北农业大学动物医学院,黑龙江,哈尔滨,150030 3. 辽宁省沈阳市动物防疫站,辽宁,沈阳,110031 |
| 摘 要： | 选用30日龄健康海兰鸡65只,按5mg／kg体重口服给予司帕沙星,定期采样,以高效液相色谱法测定血浆、肝、肾、心、肺和肌肉中司帕沙星的含量,研究司帕沙星在鸡体内的药动学与残留。结果表明:司帕沙星在血液中经时过程符合一级吸收二室开放模型,其主要动力学参数如下:t1／2α0.9585h,t1／2β11.7447h,tmax0,6514 h,Cmax0.5271 μg／ml,AUC1.7908mg／L／h。肾脏、心脏的药时数据符合一级吸收二项指数方程,其主要动力学参数分别为:t1/2Ka0.3733 h、0.1530h,t1／2k1.3007 h、2.1013h,tmax1.01420h、0.6239 h,Cmax2.1104μg／ml、1.6721 μg／ml,AUC6.51764 mg／L／h、6.2286mg／L／h。司帕沙星在肝脏、肺脏、肌肉中的经时过程符合一级吸收三项指数方程,主要动力学参数分别为t1/2α0.3672 h、0.6156 h、1.5835 h,t1/2β3.9998 h、15.0271 h、12.0103h,tmax0.7458 h、0.7322 h、1.3726 h,Cmax4.4709μg／ml、2.5267μg／ml、0.9760μg／ml,AUC20.893 mg／L／h,27.242 mg／L／h、9.7943mg/L/h。建议司帕沙星在鸡体内的休药期为7d。 |
| 关 键 词： | 司帕沙星 鸡 药代动力学 残留 |
| 文章编号： | 1672-9692(2004)11-0037-03 |
| 修稿时间： | 2004年9月22日 |
Studies on Pharmacokinetics and Residues of Sparfloxacin in Chickens |
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| LIU Mingchun,TONG Hengmin,ZHU Wenbo,SUN Xiangzhi,HE Jianbin,ZHAO YujunCollege of Animal Husbandry and Veterinary Medicine Shenyang Agricultural University,Shenyang , College of Veterinary Medicine Northeast Agricultural University,Harbin ,Shenyang animal epidemic prevention station,shenyang.Studies on Pharmacokinetics and Residues of Sparfloxacin in Chickens[J].Modern JOurnal of Animal Husbandry and Veterinary Medicine,2004(11):37-39. | |
| Authors: | LIU Mingchun TONG Hengmin ZHU Wenbo SUN Xiangzhi HE Jianbin ZHAO YujunCollege of Animal Husbandry and Veterinary Medicine Shenyang Agricultural University Shenyang College of Veterinary Medicine Northeast Agricultural University Harbin Shenyang animal epidemic prevention station shenyang |
| Institution: | LIU Mingchun,TONG Hengmin,ZHU Wenbo,SUN Xiangzhi,HE Jianbin,ZHAO YujunCollege of Animal Husbandry and Veterinary Medicine Shenyang Agricultural University,Shenyang 110161, College of Veterinary Medicine Northeast Agricultural University,Harbin 150030,Shenyang animal epidemic prevention station,shenyang 110031 |
| Abstract: | |
| Keywords: | Sparfloxacin chickens pharmacokinetics residues |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |