Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy |
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| Authors: | B W Keene D P Panciera C E Atkins V Regitz M J Schmidt A L Shug |
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| Affiliation: | Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706. |
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| Abstract: | Dilated cardiomyopathy in a family of dogs was found to be associated with decreased myocardial L-carnitine concentrations, when compared with those in control dogs. In 2 affected dogs, treatment with high doses of L-carnitine was associated with increased myocardial L-carnitine concentration and greatly improved health and myocardial function. Withdrawal of L-carnitine supplementation from these dogs resulted in development of myocardial dysfunction and clinical signs of dilated cardiomyopathy. |
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