Cytotoxicity of withanolides isolated from Acnistus arborescens |
| |
| Authors: | Claudia P Cordero Sandra J Morantes Alexandra Pez Javier Rincn Fabio A Aristizbal |
| |
| Institution: | aCancer Pharmacogenetics Research Group, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Carrera 30 No 45-03, Edificio 450, Ciudad Universitaria, Bogotá D.C., Colombia;bBioactive Principles in Medicinal Plants Research Group, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Carrera 30 No 45-03, Edificio 450, Ciudad Universitaria, Bogotá D.C., Colombia |
| |
| Abstract: | A new withanolide identified by spectroscopic analysis as 12β-acetoxy-4-deoxy-5,6-deoxy-Δ5–withanolide D and Withanolide D, were isolated from the leaves of Acnistus arborescens. Cytotoxic activity of these two compounds against human tumor cell lines HT-29, MCF-7, MKN-45, HEp-2, HeLa, U-937 and two human normal fibroblast cultures, Fib04 and Fib05, were assessed. Withanolide D presented in vitro cytotoxic activity against tumor cell lines at the low micromolar range (LC50:1.0 to 1.69 µM) and showed a slightly lower activity against Fib04, suggesting moderated selectivity among tumoral and normal cells. No cytotoxic effect was observed for 12β-acetoxy-4-deoxy-5,6-deoxy-Δ5–withanolide D. |
| |
| Keywords: | Withanolides Acnistus arborescens Solanaceae In vitro cytotoxicity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
