| Abstract: | Specific rejection of sterile orthotopic skin homografts by the fetal lamb in utero was unaccompanied by the presence of plasma cells in either the graft and its bed, or in the reactive draining lymph node. The grafts appeared not to stimulate the production of circulating immunoglobulins. The presence in the fetal circulation of rabbit anti-sheep 7S gamma-globulin and anti-beta(2M)-globulin did not inhibit the normal course of homograft rejection. These data support the contention that conventional circulating antibody is not an obligatory participant in the rejection of solid-tissue homografts. |
