Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein |
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Authors: | Clancy D J Gems D Harshman L G Oldham S Stocker H Hafen E Leevers S J Partridge L |
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Institution: | Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK. |
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Abstract: | The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved. |
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