3，13-酯基中乌头碱衍生物的合成及其杀虫活性的研究

1材料与方法1．1材料与试剂中乌头碱（1）由笔者所在的课题组从附子中提取分离。稻褐飞虱和苜蓿蚜均为室内常年累代饲养或从田间采集室内饲养多代虫种。熔点用显微熔点仪测定，温度计未校正；核磁共振谱用Bruker Avance600核磁共振仪测定（溶剂为CDCl3．TMS为内标）；质谱用Varian1200LC／MS液相色谱-质谱联用仪测定；KBiI4作生物碱特征显色剂；层析用硅胶为青岛海洋化工出品；所用试剂和溶剂均为分析纯。

Synthesis and Insecticidal Activity of Derivants of 3,13-Ester Mesaconitine

[Objective] The experiment aimed to explore the relations between structure of aconitine, aconitine derivatives and insecticide. [Method] The aconitine derivatives such as 3-acetyl mesaconitine, 3-propionyl mesaconitine, 3-acetyl-13-Benzoyl-mesaconitine and 3-propionyl-13-Benzoyl-mesaconitine were synthesized by mesaconitine with acetic anhydride or propionic anhydride and their insecticidal activities were also determined. [Result] When the concentration was 500 mg/L, the insecticidal activities of mesaconitine against Nilaparvata legen and Aphis were 50% and 30% respectively while the insecticidal activities of 3-acetyl mesaconitine, 3-propionyl mesaconitine, 3-acetyl-13-Benzoyl-mesaconitine and 3-propionyl-13-Benzoyl-mesaconitine against Aphis medicagini were 40%, 30%, 30% and 20% respectively at 500 mg/L. [Conclusion] After hydroxyl esterification, the insecticidal activity of mesaconitine was declined and the existence of hydroxyl at 3rd position in mesaconitine played very important influences on insecticidal activity.