Aurantoside K, a new antifungal tetramic acid glycoside from a Fijian marine sponge of the genus Melophlus |
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| Authors: | Kumar Rohitesh Subramani Ramesh Feussner Klaus-D Aalbersberg William |
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| Affiliation: | Centre for Drug Discovery and Conservation, Institute of Applied Sciences, The University of the South Pacific, Suva, Fiji Islands. |
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| Abstract: | A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (1H NMR, 1H-1H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp. |
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| Keywords: | marine sponges aurantosides antifungal tetramic acid glycoside Melophlus sp. |
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