| 鸡端粒酶催化亚基活性中心结构的预测与定位 |
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| 引用本文： | 刘丹,汉丽梅,潘永荣.鸡端粒酶催化亚基活性中心结构的预测与定位[J].中国家禽,2007,29(12):23-25. |
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| 作者姓名： | 刘丹 汉丽梅 潘永荣 |
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| 作者单位： | 沈阳农业大学畜牧兽医学院,辽宁沈阳,110161 |
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| 摘 要： | 研究利用已知脊椎动物端粒酶催化亚基及其活性中心的结构,依据比较基因组学理论,通过序列比对和同源性分析,对鸡端粒酶催化亚基(chTERT)活性中心序列进行预测与定位。结果表明,chTERT活性中心序列为长1813bp,位于鸡chTERT全序列的2013～3825bp位置。chTERT活性中心的确定为今后以鸡端粒酶催化亚基为靶标的抗肿瘤研究奠定基础。
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| 关 键 词： | 鸡 端粒酶催化亚基 活性中心 定位 |
| 修稿时间： | 2007-02-152007-04-19 |
Prediction and Localization of the Active Site of Chicken Telomerase Catalytic Subunit |
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| Liu Dan,Han Limei,Pan Yongrong.Prediction and Localization of the Active Site of Chicken Telomerase Catalytic Subunit[J].China Poultry,2007,29(12):23-25. |
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| Authors: | Liu Dan Han Limei Pan Yongrong |
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| Institution: | College of Animal Husbandry and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning 110161 |
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| Abstract: | According to comparative genomics,active site of chicken telomerase catalytic subunit(chTERT) was predicted and localized by homology and alignment based on published structure of vertebrate telomerase catalytic subunit. As results,the cDNA sequence of chTERT active site is 1 813 bp,localized between 2 013 bp and 3 825 bp in the complete cDNA sequence of chTERT. An active site of chTERT as an exactly target sequence can contribute to study in the field of anti-tumor. |
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| Keywords: | chicken telomerase catalytic subunit active site localization |
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