Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma |
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| Authors: | Manjuan Liu David R Katerere Alexander I Gray Vronique Seidel |
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| Institution: | aNatural Products Research Laboratories, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK;bPROMEC Unit, Medical Research Council, P.O. Box 19070, Tygerberg 7500, Cape Town, South Africa |
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| Abstract: | Phytochemical investigation of the stem bark of Terminalia mollis afforded friedelin (1), catechin with epicatechin (2), gallocatechin with epigallocatechin (3) and 3-O-methylellagic acid 4'-O-α-rhamnopyranoside (4). Arjunolic acid with 2α, 3β, 23-trihydroxy-urs-12-en-28-oic acid (5), 2α-hydroxyursolic acid (6), gallic acid (7), chebulanin (8) and 2'-O-galloylvitexin (9) were isolated from the leaf. Chebulanin (8), betulinic acid (10), ursolic acid (11), catechin (12), isoorientin (13), orientin (14), isovitexin (15) and punicalagin (16) were isolated from Terminalia brachystemma leaf. The first full unambiguous NMR assignments for (4) and (8), and revised assignments for (9), are reported. Compound (16) showed good activity against three Candida species. |
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| Keywords: | Terminalia mollis Terminalia brachystemma Combretaceae Punicalagin Antifungal activity |
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