RADIOGRAPHIC BONE LOSS CORRELATIONS AND TECHNETIUM-99m-MDP BONE UPTAKE IN LIGATURE-INDUCED PERIODONTAL DISEASE IN THE BEAGLE |
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Authors: | Merrilee Holland DVM MS J. Gregg Boring DVM MS Carolyn R. Boyle PHD Harvey M. Pickrum PHD Marjorie K. Jeffcoat DMD |
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Affiliation: | College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762-9825;Procter and Gamble Co., Miami Valley Lab, Cincinnati, OH 45241;University of Alabama at Birmingham Medical School, Birmingham, AL 35294. |
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Abstract: | The goal of this study was to develop an animal model for the study of acute periodontal disease using silk ligatures in combination with a soft diet in eleven purebred beagle dogs. The silk ligatures were placed subgingivally on the mandible second and fourth premolar on one side of the mouth; the opposite side served as a control. Dogs were monitored during the 16–20 weeks of ligature placement, and for 48 weeks after ligature removal. Development of periodontal disease was evaluated by radiopharmaceutical uptake into bone, radiographic evidence of alveolar bone loss, attachment loss, gingival index and prostaglandin level. Bone loss occurred on the ligatured side during the ligature phase of the study. Radiopharmaceutical uptake was correlated with radiographic evidence of bone loss during the ligature phase. No significant bone loss occurred during the post-ligature phase. Progressive periodontal disease was induced during ligature placement. However, a chronic less aggressive form was not sustained by soft diet alone after ligature removal. |
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Keywords: | beagle dog bone scan periodontal disease cadium telluride semiconductor probe alveolar bone reabsorption dog model |
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