| Institution: | aDepartamento de Farmacologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, PR, Brazil;bDepartamento de Química, Centro de Ciências Físicas e Matemáticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil;cDepartamento de Botânica, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, PR, Brazil |
| Abstract: | The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID50 84.0 (54.8–128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H+,K+-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE. |
