不同妊娠状态伊犁马心率变异性变化规律研究

【目的】研究流产伊犁马与正常分娩伊犁马在妊娠期心率变异性(HRV)的变化规律,以防止不良妊娠结局的发生。【方法】选取妊娠时间为29孕周的伊犁马21匹(其中流产5匹,正常分娩16匹)及7匹空怀伊犁马,分别在妊娠中期第30孕周,妊娠后期第45孕周及分娩前后1天对母马进行24 h HRV采集,包括时域指标:全部R-R间期的平均值(Mean RR)、全部R-R间距的标准差(SDNN)、平均心率(Mean HR)、相邻R-R间期差值的均方根(RMSSD)、相邻R-R间距差＞50 ms的个数(NN50)和相邻R-R-间距差＞50 ms的个数占总心跳次数的百分比(pNN50);频域指标:极低频率(VLF)、低频功率(LF)和高频功率(HF);非线性指标:全部R-R间距的标准差(Y)(SD1)、全部R-R间距的标准差(X)(SD2)。【结果】时域指标中,流产组和正常分娩组Mean RR、SDNN、RMSSD、NN50、pNN50极显著或显著低于空怀组(P＜0.01;P＜0.05),Mean HR极显著高于流产组和正常分娩组(P＜0.01);频域指标中,流产组和正常分娩组HF、LF极显著低于空怀组(P＜0.01),流产组和空怀组母马VLF极显著高于正常分娩组(P＜0.01)。非线性指标中,流产组和正常分娩组SD1和SD2极显著或显著低于空怀组(P＜0.01;P＜0.05),正常分娩组母马SD2/SD1极显著高于流产组和空怀组(P＜0.01)。【结论】伊犁马心率变异性在不同妊娠状态下均呈波动变化,Mean HR、Mean RR、SD2/SD1值在妊娠母马中出现上升,母马在妊娠过程中副交感神经占主导,自主神经系统受到抑制,流产母马VLF指标出现升高,在流产发生前后交感神经占主导,自主神经系统产生兴奋。

Study on the Change Pattern of Heart Rate Variability of Yili Horse in Different Pregnancy States

【Objective】 To study the changes of heart rate variability (HRV) between aborted Yili horse and normal delivery Yili horse during pregnancy,so as to prevent adverse pregnancy outcomes.【Method】 21 Yili horses (5 aborted and 16 delivered normally) with pregnancy for 29 weeks and 7 Yili horses non-pregnancy were selected in the third trimester of pregnancy,24-hour heart rate variability (HRV) was collected at the 30th gestational week in the second trimester,the 45th gestational week in the third trimester as well as 1 day before and after delivery.Including time domain indexes:Mean of all R-R intervals (Mean RR),standard deviation of R-R intervals (SDNN),mean heart rate (Mean HR),root mean square of successive differences (RMSSD),normal- normal intervals that differ by＞50 ms in the total number of RR intervals (NN50) and percentage of normal- normal intervals that differ by＞50 ms in the total number of RR intervals (pNN50);Frequency domain index:very low frequency (VLF),low frequency power (LF) and high frequency power (HF);Nonlinear index:Standard deviation of all R-R spacing (Y) (SD1) and standard deviation of all R-R spacing (X) (SD2).【Result】 In time domain indexes,Mean RR,SDNN,RMSSD,NN50 and pNN50 in abortion group and normal delivery group were extremely significantly or significantly lower than those in non-pregnancy group (P＜0.01;P＜0.05),Mean HR was extremely significantly higher than that in abortion group and normal delivery group (P＜0.01).In frequency domain indexes,HF and LF in abortion group and normal delivery group were extremely significantly lower than those in non-pregnant group (P＜0.01),VLF in abortion group and non-pregnant group were extremely significantly higher than that in normal delivery group (P＜0.01).In the nonlinear indexes,SD1 and SD2 in abortion group and normal delivery group were extremely significantly or significantly lower than those in non-pregnant group (P＜0.01;P＜0.05),SD2/SD1 in normal delivery group was extremely significantly higher than that in abortion group and pregnant group (P＜0.01).【Conclusion】 HRV of Yili horses fluctuated in different gestational states.Mean HR,Mean RR and SD2/SD1 values increased in pregnant mares.The parasympathetic nerve dominated the mare during gestation,and the autonomic nervous system was inhibited.The VLF index of aborted mares increased.Before and after the occurrence of abortion sympathetic nerves dominate,the autonomic nervous system produces excitement.