Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum |
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Authors: | Chao Louis Kuoping Hua Kuo-Feng Hsu Hsien-Yeh Cheng Sen-Sung Liu Ju-Yun Chang Shang-Tzen |
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Institution: | Department of Biological Science and Technology, Chung Hwa College of Medical Technology, Tainan 717, Taiwan. |
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Abstract: | The leaf essential oil from indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) was investigated by gas chromatography-mass spectrometry, and 21 compounds were identified. The major constituents of leaf essential oil were the monoterpenes 1,8-cineole (17.0%) and santolina triene (14.2%) and the sesquiterpenes spathulenol (15.7%) and caryophyllene oxide (11.2%). In the antiinflammatory activity assay, we demonstrated that the essential oil has a higher capacity to inhibit proIL-1beta protein expression induced by LPS-treated J774A.1 murine macrophage. At dosages of 60 microg/mL, essential oil clearly inhibited proIL-1beta protein expression. Furthermore, a dose of 60 microg/mL of essential oil was effectively inhibitory for IL-1beta and IL-6 production but not for TNF-alpha, suggesting that essential oil was bioactive in antiinflammation in vitro. This study is the first to report antiinflammatory activity of extracts obtained from the leaf essential oil of C. osmophloeum. |
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