酪蛋白酶解产物对仔猪肠道黏膜IGF-I及其受体基因mRNA水平的影响

研究了酪蛋白酶解产物对新生仔猪肠道黏膜胰岛素样生长因子I（IGF-I）及其受体基因mRNA水平的影响。从五窝仔猪中选出10头仔猪，每窝选2头，分别分至酪蛋白饲喂组（对照组）和酶解酪蛋白饲喂组（试验组）。两组仔猪均以牛乳为基础日粮，并分别加入1．59，6的酪蛋白和酪蛋白酶解液取代10％体积的牛乳，人工饲喂3d后屠宰取样。试验结果表明，试验组仔猪空肠黏膜IGFI受体基因和IGFI基因mRNA水平分别显著（P〈0．05）和极显著（P〈0．01）高于对照组仔猪。说明酪蛋白酶解产物促进肠道发育可能与提高IGFI及其受体基因的mRNA水平有关。

Effect of Pre-hydrolyzed Casein on The mRNA Levels of Insulin-like Growth Factor I and Its Receptors in the Mucosa of Small Intestine in Piglets

The experiment was carried out to study the effect of pre-hydrolyzed casein on the expressions of insulin-like growth factor I(IGF-I) and its receptors(IGF-IR) in the mucosa of small intestine in piglets.Ten piglets from 5 litters were randomly divided into control group(n=5),which was fed casein,and treatment group(n=5),which was fed pre-hydrolyzed casein.The experimental piglets were artificially fed for 3 days and then anesthetized and sampled.The expression levels of IGF-IR and IGF-I in the mucosa of jejunum in treatment group were significantly(P<0.05)and extremely(P<0.05) higher than that in control group,respectively.Results suggested that pre-hydrolyzed casein might stimulate the development of small intestinal via increasing the expression levels of IGF-I and IGF-IR in the intestinal mucosa.