大鼠不同时期乳腺组织及血清中孕激素变化规律

探讨大鼠不同时期乳腺组织及血液中孕激素（P）变化规律。选择雌性SD大鼠42只，分为7个时期，每个时期6只：分别为处女期，妊娠第6天、12天、18天，泌乳第6天、12天、18天。分别处死大鼠取乳腺组织及血清，通过放射免疫检测不同时期孕激素含量。结果表明血清中：处女期P含量最低，妊娠后呈现上升趋势，其中妊娠18d与各个时期差异显著（P〈0．05）；泌乳后又呈现下降趋势。7个时期中处女期与其它6个时期差异显著（P〈0．05）；乳腺组织：7个时期整体呈下降趋势，并且处女期与妊娠、泌乳整个时期差异显著（P〈0．05）。结果显示：孕激素在乳腺细胞发育、启动和维持泌乳方面发挥重要作用。

The level of Progesterone in serum and mammary tissue during all stages of mammary development

Different stages of rat mammary tissue and blood progesterone(P) variation.42 female SD rats were selected,divided into seven periods,each period 6: are virgin period,pregnancy,6 days,12 days,18 days of lactation the first 6 days,12 days,18 days.Rats were;sacrificed to take the breast tissue and serum.By radioimmunoassay of progesterone levels at different times.The reswlt showed that Serum:P content of virgin minimum period,pregnancy on the rise,18d and various periods of pregnancy in which significant differences(P <0.05);after lactation have shown a downward trend.Seven times in the Virgin during the period and the other six significant differences(P <0.05);breast tissue: the period of seven overall downward trend,and the Virgin stage of pregnancy,lactation significantly different throughout the period(P <0.05).The results showed that: progesterone in breast cell growth,initiate and maintain lactation play an important role.