乳酸恩诺沙星可溶性粉在鸡体内的药动学研究

24只苏禽黄羽肉鸡随机分成2组,分别按10 mg/kg体重剂量静注和内服乳酸恩诺沙星。测定乳酸恩诺沙星在鸡体内的药动学参数和生物利用度。恩诺沙星血药浓度数据用3p87计算机软件处理。静注乳酸恩诺沙星后的血药浓度-时间数据符合二室开放模型,主要动力学参数:t1/2α(0.45±0.16)h,t1/2β(7.02±1.42)h,CL(s)(0.38±0.10)L/kg/h,AUC(23.69±5.56)(mg/L)×h。内服乳酸恩诺沙星的血药浓度时间数据,符合有吸收因素二室模型,主要动力学参数:t1/2ka(0.60±0.01)h,t1/2ke(8.25±1.73)h,tpeak(2.44±0.17)h,Cmax(1.44±0.30)mg/L,AUC(20.74±3.80)(mg/L)×h,F 87.54%。结果表明,乳酸恩诺沙星可溶性粉在鸡体内具有吸收快、分布广、消除较慢以及内服生物利用度高的药动学特征。

Pharmacokinetic of enrofloxacin lactate soluble powder in chickens

The pharmacokinetics and bioavailability of enrofloxacin lactate were investigated in 24 healthy Suqin yellow chickens following single intravenous and oral(10 mg/kg b.w.) administration.The concentrations of enrofloxacin lactate were determined by high-performance liquid chromatography(HPLC) and the plasma concentration-time data was analyzed by the pharmacokinetic computer program 3p87.Following intravenous administration,the drug concentration-time data was best described by a two-compartment open model.The main pharmacokinetic parameters of enrofloxacin lactate were: t1/2α(0.45±0.16) h,t1/2β(7.02±1.42) h,CL(s)(0.38±0.10) mg/kg/h,AUC(23.69±5.56)(mg/L) ×h.The drug concentration-time data was best described by a two-compartment open model after oral administration with t1/2ka(0.60±0.01)h,t1/2ke(8.25±1.73)h,tpeak(2.44±0.17) h,Cmax(1.44±0.30) mg/L,AUC(20.74±3.80)(mg/L) ×h,F 87.54%.The results showed that the pharmacokinetic characteristics of enrofloxacin lactate in healthy Suqin yellow chickens manifested with the rapid absorption,wide distribution and slow elimination.The bioavailability was high by the oral routes.