Disposition kinetics of 2-pyridine aldoxime methochloride in Bubalus bubalis

2-Pyridine aldoxime methochloride (2-PAM), an acetylcholinesterase (AChE) reactivator, is widely used in the treatment of organophos-phate intoxication in man and animals (Taylor, 1980; Hatch, 1982). Among other factors, the therapeutic efficacy of AChE reactivators is dependent on the use of a suitable dosage regimen, so that during the course of therapy the concentration of drug in blood and target organs should not fall below the minimum effective concentration. Disposition kinetics of 2-PAM have been calculated in man and laboratory animals (Sidell & Groff, 1971; Swartz & Sidell, 1974; DasGupta et al. , 1979). In the present study we have investigated disposition kinetics and dosage regimen of 2-PAM and its effects on various blood enzymes in male buffalo calves after a single intravenous administration.