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Epinephrine metabolism in mammalian brain after intravenous and intraventricular administration |
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| Authors: | A M Steinman S E Smerin J D Barchas |
| Abstract: | Epinephrine given intravenously or intraventricularly has a half-life in the brain of the rat of 2 to 2.5 hours. After intravenous administration of the drug the principal route of metabolism is O-methylation, whereas after intraventricular administration the principal route is conjugation. |
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