| 细胞色素C与细胞凋亡研究进展 |
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| 引用本文： | 王艳杰,邓雯,张鹏飞.细胞色素C与细胞凋亡研究进展[J].动物医学进展,2012,33(7):89-92. |
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| 作者姓名： | 王艳杰 邓雯 张鹏飞 |
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| 作者单位： | 河南科技大学动物科技学院,河南洛阳,471003 |
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| 摘 要： | 在细胞凋亡过程中,线粒体是调控细胞凋亡的中心,而细胞色素C(Cyt-C)从线粒体的释放则起着关键性作用。细胞色素C释放到胞质后可激活Caspase,引发级联反应,从而导致凋亡;Bcl-2蛋白家族具有调控细胞色素C释放的功能;凋亡诱导因子AIF保证着凋亡的有序进行;内质网(ER)通过应激、招募、活化等提高线粒体对促凋亡因子的敏感性,从而使细胞色素C从线粒体线粒体膜间隙(intermembrane space,IMS)释放,发挥了重要的作用。
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| 关 键 词： | 细胞色素C 细胞凋亡 调控途径 |
Progress on Cytochrome C and Cell Apoptosis |
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| WANG Yan-jie
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DENG Wen
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ZHANG Peng-fei.Progress on Cytochrome C and Cell Apoptosis[J].Progress In Veterinary Medicine,2012,33(7):89-92. |
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| Authors: | WANG Yan-jie DENG Wen ZHANG Peng-fei |
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| Institution: | (College of Animal Science and Technology,Henan University of Science and Technology,Luoyang,Henan,471003,China) |
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| Abstract: | In the process of apoptosis,mitochondria are the apoptosis regulation center,and cytochrome C(Cyt-C) plays a key role in the release from mitochondria.Cytochrome C can activate caspase when cytochrome C is released into the cytoplasm,leading to apoptosis.The Bcl-2 protein family can regulates cytochrome C release.Apoptosis inducing factor AIF ensures the apoptosis in an orderly manner.Endoplasmic reticulum can improve the mitochondrial pro-apoptotic factor sensitivity through stress,recruitment,activation,therefore plays an important role in the release of cytochrome C from mitochondrial IMS. |
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| Keywords: | cytochrome C cell apoptosis regulatory route |
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